New Drug Development for Known and Emerging Viruses

Discusses how to fight?Ebola, SARS Corona,?and other known or emerging human viruses by building on the successes in antiviral therapy of the past decades? Written by leading medicinal chemists from academia and industry, this?book?discusses the entire field of antiviral drug discovery and development from a medicinal chemistry perspective, focusing on antiviral drugs, targets,?and viral disease mechanisms.?It?provides?an outlook on emerging pathogens such as Ebola,?Zika,?West Nile, Lassa,?and includes a?chapter?on?SARS?Coronoavirus-2 causing the present?pandemic.?? New Drug Development for Known and Emerging Viruses?describes the discovery and development process for antiviral agents for different classes of viruses and targets based on the?experiences?from the nine human viruses for which approved drugs are on the market (HIV, HCV, Influenza, RSV, HBV, HPV, HCMV, HSV,?and?VZV). It covers the?properties and potential of 20 classes of currently approved antivirals,?including combination drugs, and looks at novel antiviral strategies against emerging viruses.? - Covers the?entire field of antiviral drug discovery and development?? - Addresses?the?need for?antiviral drugs?to combat?major?health?threats?such as?Ebola, Zika,?West Nile, and?SARS Coronavirus-2? - Summarizes the successes of the past 15 years in developing ground-breaking medicines against 9 major human viruses, both from the medicinal chemistry and the pharmacological angle? - Discusses?practical and strategic challenges in the drug discovery and development process, including screening technologies, latency,?and toxicity issues? New Developments in Antiviral Drugs?is an?important?book for?medicinal chemists, pharmaceutical chemists, virologists,?and?epidemiologists, and will?be of great interest to those in the?pharmaceutical industry?and?public health agencies.?